Serine

Found in 2 curated pathways across 2 categories.

Interaction Network

Loading graph…

Active In Categories

metabolic lipid

Frequently Co-occurring Molecules

Tetrahydrofolate (THF)×1 5-Methyl-THF×1 5,10-Methylene-THF×1 SAM×1 SAH×1 Homocysteine×1 Methionine×1 Glycine×1 Palmitoyl-CoA×1 Sphinganine×1 Ceramide×1 Sphingomyelin×1

Frequently Co-occurring Enzymes

Dihydrofolate reductase (DHFR)×1 Thymidylate synthase×1 MTHFR×1 Methionine synthase (MS)×1 SHMT (serine hydroxymethyltransferase)×1 Serine palmitoyltransferase (SPT)×1 Ceramide synthases (CerS1-6)×1 Sphingomyelinase (acid/neutral)×1 Sphingosine kinase 1/2×1 S1P lyase×1

Cross-Referenced Pathways

2 direct · 5 cross-referenced · 7 shown

Direct Involvement

⚡

Metabolic

Folate / One-Carbon Metabolism

Transfer of one-carbon units for nucleotide synthesis, methylation, and amino acid metabolism.

Tetrahydrofolate (THF)5-Methyl-THF5,10-Methylene-THF+6

🫧

Lipid Metabolism

Sphingolipid Metabolism

Biosynthesis and degradation of sphingolipids including ceramide signaling.

SerinePalmitoyl-CoASphinganine+5

Cross-Referenced

— connected via related pathways

⚡

Metabolic

Amino Acid Catabolism

Degradation of amino acids to metabolic intermediates and ammonia.

Amino acidsα-KetoglutarateGlutamate+4

⚡

Metabolic

Nucleotide Biosynthesis

De novo and salvage pathways for purine and pyrimidine nucleotide production.

PRPPIMPAMP+6

📡

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

🧬

Genetic Information

Epigenetic Regulation

Heritable changes in gene expression without altering the DNA sequence.

5-MethylcytosineHistone H3/H4CpG islands+4

💀

Cell Death

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

BAXBAKBCL-2+7