Home/Thymidylate synthase

Enzyme

2 pathways

Thymidylate synthase

Found in 2 curated pathways across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

PRPP×1 IMP×1 AMP×1 GMP×1 UMP×1 Orotate×1 Ribose-5-phosphate×1 THF (tetrahydrofolate)×1 dNTPs×1 Tetrahydrofolate (THF)×1 5-Methyl-THF×1 5,10-Methylene-THF×1

Frequently Co-occurring Enzymes

PRPP synthetase×1 Amidophosphoribosyltransferase×1 HGPRT×1 Dihydroorotate dehydrogenase×1 Ribonucleotide reductase×1 Dihydrofolate reductase (DHFR)×1 MTHFR×1 Methionine synthase (MS)×1 SHMT (serine hydroxymethyltransferase)×1

Cross-Referenced Pathways

2 direct · 3 cross-referenced · 5 shown

Direct Involvement

2

Nucleotide Biosynthesis

De novo and salvage pathways for purine and pyrimidine nucleotide production.

Folate / One-Carbon Metabolism

Transfer of one-carbon units for nucleotide synthesis, methylation, and amino acid metabolism.

Tetrahydrofolate (THF)5-Methyl-THF5,10-Methylene-THF+6

Cross-Referenced

3

— connected via related pathways

Pentose Phosphate Pathway

Generates NADPH and ribose-5-phosphate for biosynthesis.

Glucose-6-phosphate6-PhosphogluconateRibulose-5-phosphate+3

Amino Acid Catabolism

Degradation of amino acids to metabolic intermediates and ammonia.

Amino acidsα-KetoglutarateGlutamate+4

Genetic Information

Epigenetic Regulation

Heritable changes in gene expression without altering the DNA sequence.

5-MethylcytosineHistone H3/H4CpG islands+4