Home/Sphingosine kinase 1/2

Enzyme

1 pathway

Sphingosine kinase 1/2

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Serine×1 Palmitoyl-CoA×1 Sphinganine×1 Ceramide×1 Sphingomyelin×1 Glucosylceramide×1 Sphingosine×1 S1P (sphingosine-1-phosphate)×1

Frequently Co-occurring Enzymes

Serine palmitoyltransferase (SPT)×1 Ceramide synthases (CerS1-6)×1 Sphingomyelinase (acid/neutral)×1 S1P lyase×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Lipid Metabolism

Sphingolipid Metabolism

Biosynthesis and degradation of sphingolipids including ceramide signaling.

SerinePalmitoyl-CoASphinganine+5

Cross-Referenced

2

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.