Home/ALA synthase (ALAS1/2)

Enzyme

1 pathway

ALA synthase (ALAS1/2)

Found in 1 curated pathway across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

Glycine×1 Succinyl-CoA×1 δ-Aminolevulinic acid (ALA)×1 Porphobilinogen×1 Uroporphyrinogen III×1 Protoporphyrin IX×1 Heme×1 Fe²⁺×1

Frequently Co-occurring Enzymes

ALA dehydratase×1 Porphobilinogen deaminase×1 Uroporphyrinogen decarboxylase×1 Ferrochelatase×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Heme Biosynthesis

Eight-step pathway producing heme from glycine and succinyl-CoA.

GlycineSuccinyl-CoAδ-Aminolevulinic acid (ALA)+5

Cross-Referenced

2

— connected via related pathways

Citric Acid Cycle (Krebs Cycle)

Oxidizes acetyl-CoA to CO₂, generating GTP, NADH, and FADH₂.

Acetyl-CoACitrateIsocitrate+6

Amino Acid Catabolism

Degradation of amino acids to metabolic intermediates and ammonia.

Amino acidsα-KetoglutarateGlutamate+4