Home/RhoA GTPase

Enzyme

2 pathways

RhoA GTPase

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

cell-cycle developmental

Frequently Co-occurring Molecules

RhoA×2 Actin×1 Myosin II×1 Anillin×1 Septins×1 ESCRT-III×1 Central spindle (MKLP1, CYK-4)×1 Wnt5a/Wnt11×1 Frizzled×1 Vangl1/2×1 Prickle×1 Celsr1-3×1

Frequently Co-occurring Enzymes

ROCK kinase×2 ECT2 (RhoGEF)×1 Citron kinase×1 Aurora B×1 Rac1 GTPase×1 JNK kinase×1 DAAM1 (formin)×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Cytokinesis

Physical division of the cytoplasm following nuclear division.

ActinMyosin IIRhoA+4

Planar Cell Polarity (PCP)

Non-canonical Wnt pathway coordinating tissue-level cell orientation.

Wnt5a/Wnt11FrizzledVangl1/2+6

Cross-Referenced

4

— connected via related pathways

Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5

Cell Cycle Regulation

Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.

Cyclin D/E/A/BCDK1/2/4/6Rb+5

Mitosis

Nuclear division producing two genetically identical daughter nuclei.

CondensinCohesinKinetochore proteins+3

Hedgehog Signaling Pathway

Morphogen gradient pathway controlling tissue patterning and stem cell maintenance.