Home/RhoA
Molecule
3 pathways

RhoA

Found in 3 curated pathways across 3 categories.

Interaction Network

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Active In Categories

cell-cycledevelopmentalmuscle

Frequently Co-occurring Molecules

Rac1×2Actin×1Myosin II×1Anillin×1Septins×1ESCRT-III×1Central spindle (MKLP1, CYK-4)×1Wnt5a/Wnt11×1Frizzled×1Vangl1/2×1Prickle×1Celsr1-3×1

Frequently Co-occurring Enzymes

ROCK kinase×3RhoA GTPase×2ECT2 (RhoGEF)×1Citron kinase×1Aurora B×1Rac1 GTPase×1JNK kinase×1DAAM1 (formin)×1Arp2/3 complex×1Formins×1LIMK (phosphorylates cofilin)×1PAK kinase×1

Cross-Referenced Pathways

3 direct · 7 cross-referenced · 10 shown

Cross-Referenced

7
— connected via related pathways
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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6
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Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5
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Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6
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Cell Cycle

Cell Cycle Regulation

Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.

Cyclin D/E/A/BCDK1/2/4/6Rb+5
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Cell Cycle

Mitosis

Nuclear division producing two genetically identical daughter nuclei.

CondensinCohesinKinetochore proteins+3
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Developmental

Hedgehog Signaling Pathway

Morphogen gradient pathway controlling tissue patterning and stem cell maintenance.

SHHIHHDHH+4
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Developmental

Epithelial-Mesenchymal Transition (EMT)

Cellular program converting epithelial cells to motile mesenchymal phenotype.

E-cadherinN-cadherinVimentin+5