Myosin II

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

cell-cycle muscle

Frequently Co-occurring Molecules

RhoA×2 Actin×1 Anillin×1 Septins×1 ESCRT-III×1 Central spindle (MKLP1, CYK-4)×1 G-actin×1 F-actin×1 Arp2/3 complex×1 Formins (mDia)×1 Cofilin×1 Profilin×1

Frequently Co-occurring Enzymes

ROCK kinase×2 RhoA GTPase×1 ECT2 (RhoGEF)×1 Citron kinase×1 Aurora B×1 Arp2/3 complex×1 Formins×1 LIMK (phosphorylates cofilin)×1 PAK kinase×1

Cross-Referenced Pathways

2 direct · 5 cross-referenced · 7 shown

Direct Involvement

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Cell Cycle

Cytokinesis

Physical division of the cytoplasm following nuclear division.

ActinMyosin IIRhoA+4

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Muscle & Cytoskeleton

Actin Cytoskeleton Dynamics

Rho GTPase-regulated actin polymerization driving cell shape and motility.

G-actinF-actinArp2/3 complex+8

Cross-Referenced

— connected via related pathways

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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

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Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

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Cell Cycle

Cell Cycle Regulation

Ordered progression through G1, S, G2, and M phases via cyclin-CDK complexes.

Cyclin D/E/A/BCDK1/2/4/6Rb+5

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Cell Cycle

Mitosis

Nuclear division producing two genetically identical daughter nuclei.

CondensinCohesinKinetochore proteins+3

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Developmental

Epithelial-Mesenchymal Transition (EMT)

Cellular program converting epithelial cells to motile mesenchymal phenotype.

E-cadherinN-cadherinVimentin+5