Acetylcholine

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

neuronal muscle

Frequently Co-occurring Molecules

Glutamate×1 GABA×1 Dopamine×1 Serotonin×1 Norepinephrine×1 Synaptic vesicles×1 SNARE complex (VAMP, SNAP-25, Syntaxin)×1 Ca²⁺×1 HCN channels (If)×1 L-type Ca²⁺ channels (Cav1.2)×1 Nav1.5 (SCN5A)×1 K⁺ channels (IKr, IKs, IK1)×1

Frequently Co-occurring Enzymes

Synaptotagmin (Ca²⁺ sensor)×1 Acetylcholinesterase×1 MAO (monoamine oxidase)×1 COMT×1 Glutamate decarboxylase×1 PKA×1 CaMKII×1 Adenylyl cyclase×1 Phosphodiesterases×1 Na⁺/K⁺-ATPase×1

Cross-Referenced Pathways

2 direct · 5 cross-referenced · 7 shown

Direct Involvement

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Neuronal

Synaptic Transmission

Chemical neurotransmission across synaptic clefts between neurons.

GlutamateGABAAcetylcholine+6

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Muscle & Cytoskeleton

Cardiac Conduction System

Electrical conduction system coordinating rhythmic heart contraction.

HCN channels (If)L-type Ca²⁺ channels (Cav1.2)Nav1.5 (SCN5A)+4

Cross-Referenced

— connected via related pathways

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Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

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Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4

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Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3

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Membrane Transport

Ion Channel Signaling

Selective ion flux through membrane channels driving electrical and chemical signals.

Na⁺K⁺Ca²⁺+5

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Neuronal

Dopamine Signaling

Dopaminergic neurotransmission regulating reward, motivation, and motor control.

TyrosineL-DOPADopamine+6