Home/Na⁺/K⁺-ATPase

Enzyme

2 pathways

Na⁺/K⁺-ATPase

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

transport muscle

Frequently Co-occurring Molecules

Na⁺×1 K⁺×1 Ca²⁺×1 Cl⁻×1 Nav channels×1 Kv channels×1 Cav channels×1 NMDA/AMPA receptors×1 HCN channels (If)×1 L-type Ca²⁺ channels (Cav1.2)×1 Nav1.5 (SCN5A)×1 K⁺ channels (IKr, IKs, IK1)×1

Frequently Co-occurring Enzymes

Ca²⁺-ATPase (SERCA)×1 CaMK kinases×1 PKA×1 CaMKII×1 Adenylyl cyclase×1 Phosphodiesterases×1

Cross-Referenced Pathways

2 direct · 4 cross-referenced · 6 shown

Direct Involvement

2

Membrane Transport

Ion Channel Signaling

Selective ion flux through membrane channels driving electrical and chemical signals.

Na⁺K⁺Ca²⁺+5

Muscle & Cytoskeleton

Cardiac Conduction System

Electrical conduction system coordinating rhythmic heart contraction.

HCN channels (If)L-type Ca²⁺ channels (Cav1.2)Nav1.5 (SCN5A)+4

Cross-Referenced

4

— connected via related pathways

Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4

Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3

Synaptic Transmission

Chemical neurotransmission across synaptic clefts between neurons.

GlutamateGABAAcetylcholine+6