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Molecule

1 pathway

T-bet

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

IL-12×1 IFN-γ×1 IL-4×1 IL-6×1 TGF-β×1 IL-17×1 IL-21×1 IL-10×1 GATA3×1 RORγt×1 Foxp3×1 Bcl-6×1

Frequently Co-occurring Enzymes

JAK1/2/3×1 STAT1/3/4/5/6×1 TYK2×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Immune Response

T Helper Cell Differentiation

Polarization of naive CD4+ T cells into specialized effector subsets.

IL-12IFN-γIL-4+10

Cross-Referenced

3

— connected via related pathways

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2

Immune Response

T Cell Receptor Signaling

Antigen-specific activation of T lymphocytes via TCR-MHC interaction.

TCR-CD3 complexMHC-peptideCD4/CD8+7

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5