Home/Fibronectin
Molecule
2 pathways

Fibronectin

Found in 2 curated pathways across 2 categories.

Interaction Network

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Active In Categories

developmentalmuscle

Frequently Co-occurring Molecules

E-cadherin×1N-cadherin×1Vimentin×1Snail/Slug×1Twist1/2×1ZEB1/2×1miR-200 family×1Integrins (αβ dimers)×1Collagen×1Laminin×1Talin×1Kindlin×1

Frequently Co-occurring Enzymes

GSK-3β (Snail phosphorylation)×1LOX (E-cadherin repression)×1MMPs (matrix degradation)×1FAK (focal adhesion kinase)×1Src kinase×1ILK (integrin-linked kinase)×1MLCK×1

Cross-Referenced Pathways

2 direct · 6 cross-referenced · 8 shown

Cross-Referenced

6
— connected via related pathways
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Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3
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Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6
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Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5
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Signal Transduction

Notch Signaling Pathway

Juxtacrine signaling controlling cell fate decisions via proteolytic receptor activation.

Notch 1-4 receptorsDelta-like ligands (DLL1, DLL3, DLL4)Jagged ligands (JAG1, JAG2)+3
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Developmental

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5
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Muscle & Cytoskeleton

Actin Cytoskeleton Dynamics

Rho GTPase-regulated actin polymerization driving cell shape and motility.

G-actinF-actinArp2/3 complex+8