FGFR kinase

FGF Signaling

Fibroblast growth factor signaling controlling proliferation, differentiation, and organogenesis.

FGF1-22FGFR1-4FRS2+3

Hes7/Her1 (oscillators)LFNG (Notch modifier)Axin2 (Wnt target)+4

Somitogenesis (Segmentation Clock)

Oscillating gene expression driving periodic formation of somites.

Cross-Referenced

— connected via related pathways

Growth factors (EGF, PDGF)RAS-GTPRAF+3

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Wnt ligandsFrizzled receptorLRP5/6+5

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Notch 1-4 receptorsDelta-like ligands (DLL1, DLL3, DLL4)Jagged ligands (JAG1, JAG2)+3

Notch Signaling Pathway

Juxtacrine signaling controlling cell fate decisions via proteolytic receptor activation.

Hedgehog Signaling Pathway

Morphogen gradient pathway controlling tissue patterning and stem cell maintenance.

SHHIHHDHH+4