Home/TNF/TNFR1

Molecule

2 pathways

TNF/TNFR1

Found in 2 curated pathways across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

FasL/Fas×1 TRAIL/DR4/DR5×1 FADD×1 TRADD×1 c-FLIP×1 tBID×1 RIPK1×1 RIPK3×1 MLKL×1 cIAP1/2×1 DAMPs (HMGB1, ATP)×1

Frequently Co-occurring Enzymes

Caspase-8 (initiator)×1 Caspase-10×1 Caspase-3/7 (executioner)×1 RIPK1 kinase×1 RIPK3 kinase×1 MLKL (pseudokinase/effector)×1 Caspase-8×1

Cross-Referenced Pathways

2 direct · 3 cross-referenced · 5 shown

Direct Involvement

2

Extrinsic Apoptosis (Death Receptor)

Cell death initiated by death ligand-receptor interactions at the cell surface.

FasL/FasTNF/TNFR1TRAIL/DR4/DR5+4

Necroptosis

Regulated necrotic cell death mediated by RIPK1-RIPK3-MLKL signaling.

RIPK1RIPK3MLKL+3

Cross-Referenced

3

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Immune Response

Inflammasome Pathway

Intracellular sensor complexes activating inflammatory caspases and IL-1β/IL-18.

NLRP3ASCPro-caspase-1+6

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.