Home/TRAIL/DR4/DR5

Molecule

1 pathway

TRAIL/DR4/DR5

Found in 1 curated pathway across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

FasL/Fas×1 TNF/TNFR1×1 FADD×1 TRADD×1 c-FLIP×1 tBID×1

Frequently Co-occurring Enzymes

Caspase-8 (initiator)×1 Caspase-10×1 Caspase-3/7 (executioner)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Extrinsic Apoptosis (Death Receptor)

Cell death initiated by death ligand-receptor interactions at the cell surface.

FasL/FasTNF/TNFR1TRAIL/DR4/DR5+4

Cross-Referenced

2

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.