Home/MLKL (pseudokinase/effector)

Enzyme

1 pathway

MLKL (pseudokinase/effector)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

RIPK1×1 RIPK3×1 MLKL×1 TNF/TNFR1×1 cIAP1/2×1 DAMPs (HMGB1, ATP)×1

Frequently Co-occurring Enzymes

RIPK1 kinase×1 RIPK3 kinase×1 Caspase-8×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Necroptosis

Regulated necrotic cell death mediated by RIPK1-RIPK3-MLKL signaling.

RIPK1RIPK3MLKL+3

Cross-Referenced

3

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Immune Response

Inflammasome Pathway

Intracellular sensor complexes activating inflammatory caspases and IL-1β/IL-18.

NLRP3ASCPro-caspase-1+6

Extrinsic Apoptosis (Death Receptor)

Cell death initiated by death ligand-receptor interactions at the cell surface.

FasL/FasTNF/TNFR1TRAIL/DR4/DR5+4