Home/Caspase-3 (executioner)

Enzyme

1 pathway

Caspase-3 (executioner)

Found in 1 curated pathway across 1 category.

Interaction Network

Loading graph…

Active In Categories

Frequently Co-occurring Molecules

BAX×1 BAK×1 BCL-2×1 BCL-XL×1 MCL-1×1 BIM×1 BID×1 Cytochrome c×1 APAF-1×1 Smac/DIABLO×1

Frequently Co-occurring Enzymes

Caspase-9 (initiator)×1 Caspase-7 (executioner)×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

Cross-Referenced

3

— connected via related pathways

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Cell Cycle Checkpoints

Surveillance mechanisms ensuring genomic integrity at each cell cycle phase.

Extrinsic Apoptosis (Death Receptor)

Cell death initiated by death ligand-receptor interactions at the cell surface.

FasL/FasTNF/TNFR1TRAIL/DR4/DR5+4