🚪
Membrane Transport
Eukaryotes
Vesicular Transport (Secretory Pathway)
ER-to-Golgi-to-plasma membrane trafficking via coated vesicles.
Overview
The secretory pathway transports proteins from ER through Golgi to plasma membrane or lysosomes. COPII vesicles mediate ER-to-Golgi transport, COPI handles retrograde transport. SNARE proteins drive membrane fusion.
Cellular Location
ER → Golgi → plasma membrane / lysosomes
Clinical Significance
Essential for protein secretion; defects cause cystic fibrosis (CFTR misfolding) and congenital disorders of glycosylation.