Home/TGR5

Molecule

1 pathway

TGR5

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Cholesterol×1 7α-Hydroxycholesterol×1 Cholic acid×1 Chenodeoxycholic acid×1 Deoxycholic acid×1 Glyco/tauro-conjugates×1 FXR×1

Frequently Co-occurring Enzymes

CYP7A1 (rate-limiting)×1 CYP8B1×1 CYP27A1×1 BSEP (bile salt export pump)×1 ASBT (ileal reuptake)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Lipid Metabolism

Bile Acid Synthesis

Hepatic conversion of cholesterol to bile acids for lipid digestion and signaling.

Cholesterol7α-HydroxycholesterolCholic acid+5

Cross-Referenced

2

— connected via related pathways

β-Oxidation of Fatty Acids

Sequential removal of 2-carbon units from fatty acids as acetyl-CoA.

Fatty acyl-CoAAcetyl-CoACarnitine+5

Lipid Metabolism

Cholesterol Biosynthesis (Mevalonate Pathway)

Multi-step synthesis of cholesterol from acetyl-CoA via the mevalonate pathway.

Acetyl-CoAHMG-CoAMevalonate+8