RXRα/β/γ

Found in 3 curated pathways across 2 categories.

Interaction Network

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Active In Categories

developmental endocrine

Frequently Co-occurring Molecules

RXR×2 Retinol×1 Retinaldehyde×1 ATRA×1 RARα/β/γ×1 CRABP1/2×1 CYP26×1 TRH×1 TSH×1 T4 (thyroxine)×1 T3 (triiodothyronine)×1 rT3×1

Frequently Co-occurring Enzymes

RDH10×1 RALDH1/2/3×1 CYP26A1/B1/C1×1 TPO (thyroid peroxidase)×1 DIO1/2/3 (deiodinases)×1 NIS (sodium-iodide symporter)×1 MCT8 (T3 transporter)×1 CYP2R1 (25-hydroxylase)×1 CYP27B1 (1α-hydroxylase)×1 CYP24A1 (24-hydroxylase, inactivation)×1

Cross-Referenced Pathways

3 direct · 5 cross-referenced · 8 shown

Direct Involvement

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Developmental

Retinoic Acid Signaling

Vitamin A-derived morphogen controlling anterior-posterior patterning.

RetinolRetinaldehydeATRA+4

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Endocrine

Thyroid Hormone Signaling

T3/T4 regulation of metabolism, growth, and development via nuclear receptors.

TRHTSHT4 (thyroxine)+6

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Endocrine

Vitamin D Signaling

Vitamin D3 activation and nuclear receptor signaling for calcium homeostasis.

Vitamin D3 (cholecalciferol)25(OH)D (calcidiol)1,25(OH)₂D (calcitriol)+6

Cross-Referenced

— connected via related pathways

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Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5

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Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

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Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4

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Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3

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Developmental

Hedgehog Signaling Pathway

Morphogen gradient pathway controlling tissue patterning and stem cell maintenance.

SHHIHHDHH+4