Home/DIO1/2/3 (deiodinases)

Enzyme

1 pathway

DIO1/2/3 (deiodinases)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

TRH×1 TSH×1 T4 (thyroxine)×1 T3 (triiodothyronine)×1 rT3×1 TRα/β×1 RXR×1 Thyroglobulin×1 Iodide×1

Frequently Co-occurring Enzymes

TPO (thyroid peroxidase)×1 NIS (sodium-iodide symporter)×1 MCT8 (T3 transporter)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Thyroid Hormone Signaling

T3/T4 regulation of metabolism, growth, and development via nuclear receptors.

TRHTSHT4 (thyroxine)+6

Cross-Referenced

2

— connected via related pathways

Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3