Home/Fatty acid synthase (FAS/FASN)

Enzyme

1 pathway

Fatty acid synthase (FAS/FASN)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Acetyl-CoA×1 Malonyl-CoA×1 Citrate×1 NADPH×1 Palmitate (C16:0)×1 ACP (acyl carrier protein)×1 Biotin×1

Frequently Co-occurring Enzymes

ACC (acetyl-CoA carboxylase)×1 ATP-citrate lyase×1 Malic enzyme×1 SREBP-1c (transcription factor)×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Lipid Metabolism

De Novo Fatty Acid Synthesis

Cytoplasmic synthesis of palmitate from acetyl-CoA and malonyl-CoA.

Acetyl-CoAMalonyl-CoACitrate+4

Cross-Referenced

3

— connected via related pathways

Citric Acid Cycle (Krebs Cycle)

Oxidizes acetyl-CoA to CO₂, generating GTP, NADH, and FADH₂.

Acetyl-CoACitrateIsocitrate+6

Pentose Phosphate Pathway

Generates NADPH and ribose-5-phosphate for biosynthesis.

Glucose-6-phosphate6-PhosphogluconateRibulose-5-phosphate+3

Signal Transduction

Insulin Signaling Pathway

Insulin receptor activation driving glucose uptake and anabolic metabolism.

InsulinInsulin receptorIRS-1/2+6