Home/Tyrosine hydroxylase (TH)

Enzyme

1 pathway

Tyrosine hydroxylase (TH)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Tyrosine×1 L-DOPA×1 Dopamine×1 D1/D5 receptors×1 D2/D3/D4 receptors×1 DAT×1 VMAT2×1 cAMP×1 DARPP-32×1

Frequently Co-occurring Enzymes

DOPA decarboxylase×1 MAO-A/B×1 COMT×1 Adenylyl cyclase×1 PKA×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Dopamine Signaling

Dopaminergic neurotransmission regulating reward, motivation, and motor control.

TyrosineL-DOPADopamine+6

Cross-Referenced

3

— connected via related pathways

Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3

Synaptic Transmission

Chemical neurotransmission across synaptic clefts between neurons.

GlutamateGABAAcetylcholine+6