Home/Tryptophan hydroxylase (TPH1/2)

Enzyme

1 pathway

Tryptophan hydroxylase (TPH1/2)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Tryptophan×1 5-HTP×1 Serotonin (5-HT)×1 5-HIAA×1 SERT×1 5-HT1A-7 receptors×1 cAMP×1 IP3/DAG×1

Frequently Co-occurring Enzymes

Aromatic AA decarboxylase×1 MAO-A×1 Adenylyl cyclase×1 PLCβ×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Serotonin (5-HT) Signaling

Serotonergic neurotransmission modulating mood, sleep, appetite, and cognition.

Tryptophan5-HTPSerotonin (5-HT)+5

Cross-Referenced

3

— connected via related pathways

Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6

Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3

Synaptic Transmission

Chemical neurotransmission across synaptic clefts between neurons.

GlutamateGABAAcetylcholine+6