Home/SMAD4

Molecule

1 pathway

SMAD4

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

TGF-β1/2/3×1 BMP2/4/7×1 Activin×1 ALK1-7×1 SMAD2/3×1 SMAD1/5/8×1 SMAD7×1

Frequently Co-occurring Enzymes

TGF-β type I receptor kinase (ALK5)×1 BMP type I receptor kinase (ALK2/3/6)×1 Smurf1/2×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

TGF-β/BMP Signaling

Multifunctional cytokine signaling controlling growth, differentiation, and immune regulation.

TGF-β1/2/3BMP2/4/7Activin+5

Cross-Referenced

2

— connected via related pathways

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5