Home/SIRT1 (BMAL1 deacetylation)

Enzyme

1 pathway

SIRT1 (BMAL1 deacetylation)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

CLOCK×1 BMAL1×1 PER1/2/3×1 CRY1/2×1 REV-ERBα/β×1 RORα/β×1 Melatonin×1 Cortisol×1

Frequently Co-occurring Enzymes

CK1δ/ε (period regulation)×1 AMPK (CRY degradation)×1 GSK-3β×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Circadian Clock Pathway

Transcription-translation feedback loops generating ~24-hour biological rhythms.

CLOCKBMAL1PER1/2/3+5

Cross-Referenced

2

— connected via related pathways

Signal Transduction

AMPK Pathway

Cellular energy sensor activating catabolic and inhibiting anabolic pathways.

Signal Transduction

cAMP/PKA Signaling

Cyclic AMP as a second messenger activating protein kinase A.

cAMPATPPKA regulatory subunits+3