Home/γ-Secretase complex (S3 cleavage)

Enzyme

1 pathway

γ-Secretase complex (S3 cleavage)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Notch 1-4 receptors×1 Delta-like ligands (DLL1, DLL3, DLL4)×1 Jagged ligands (JAG1, JAG2)×1 NICD×1 CSL/RBP-Jκ×1 MAML×1

Frequently Co-occurring Enzymes

ADAM10/17 (S2 cleavage)×1 FBXW7 (ubiquitin ligase)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Signal Transduction

Notch Signaling Pathway

Juxtacrine signaling controlling cell fate decisions via proteolytic receptor activation.

Notch 1-4 receptorsDelta-like ligands (DLL1, DLL3, DLL4)Jagged ligands (JAG1, JAG2)+3

Cross-Referenced

2

— connected via related pathways

Signal Transduction

Wnt/β-Catenin Pathway

Controls cell fate, proliferation, and polarity through β-catenin stabilization.

Wnt ligandsFrizzled receptorLRP5/6+5

Hedgehog Signaling Pathway

Morphogen gradient pathway controlling tissue patterning and stem cell maintenance.