Home/p75NTR

Molecule

1 pathway

p75NTR

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

NGF×1 BDNF×1 NT-3×1 NT-4×1 TrkA/B/C×1 Sortilin×1 Pro-neurotrophins×1

Frequently Co-occurring Enzymes

TrkA/B/C kinases×1 PLCγ×1 PI3K×1 SHC/GRB2/SOS×1 JNK (via p75)×1

Cross-Referenced Pathways

1 direct · 4 cross-referenced · 5 shown

Direct Involvement

1

Neurotrophin Signaling

Growth factor signaling promoting neuronal survival, differentiation, and plasticity.

Cross-Referenced

4

— connected via related pathways

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Intrinsic Apoptosis (Mitochondrial)

Cell death triggered by internal stress via mitochondrial cytochrome c release.

Long-Term Potentiation / Depression (LTP/LTD)

Activity-dependent strengthening or weakening of synaptic connections.

NMDA receptorAMPA receptorCa²⁺+6