Home/MEK1/2 (MAP2K)

Enzyme

1 pathway

MEK1/2 (MAP2K)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Growth factors (EGF, PDGF)×1 RAS-GTP×1 RAF×1 MEK1/2×1 ERK1/2×1 Transcription factors (Elk-1, c-Myc, c-Fos)×1

Frequently Co-occurring Enzymes

RAF kinase×1 ERK1/2 (MAPK)×1 SOS (GEF)×1 GAP×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Cross-Referenced

2

— connected via related pathways

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Signal Transduction

JAK-STAT Pathway

Cytokine-driven signaling from receptor to gene expression via STAT dimerization.

Cytokines (IL-6, IFN, EPO)JAK1/2/3, TYK2STAT1-6+2