Home/GPX4 (glutathione peroxidase 4)

Enzyme

1 pathway

GPX4 (glutathione peroxidase 4)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Fe²⁺/Fe³⁺×1 Lipid peroxides (PLOOH)×1 Glutathione (GSH)×1 Cystine×1 System Xc⁻ (SLC7A11)×1 CoQ10×1 FSP1×1

Frequently Co-occurring Enzymes

ACSL4 (acyl-CoA synthetase)×1 LOX (lipoxygenases)×1 FSP1 (ferroptosis suppressor protein 1)×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Ferroptosis

Iron-dependent regulated cell death driven by lipid peroxidation.

Fe²⁺/Fe³⁺Lipid peroxides (PLOOH)Glutathione (GSH)+4

Cross-Referenced

2

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Autophagy

Self-digestion pathway recycling cellular components via lysosomal degradation.

ULK1 complexBeclin-1VPS34+6