Home/5α-Reductase (SRD5A1/2)

Enzyme

1 pathway

5α-Reductase (SRD5A1/2)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Testosterone×1 DHT×1 DHEA×1 Androstenedione×1 Androgen receptor (AR)×1 LH×1 GnRH×1 SHBG×1

Frequently Co-occurring Enzymes

CYP17A1 (17α-hydroxylase)×1 17β-HSD×1 Aromatase (CYP19A1, converts to estrogen)×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Androgen Signaling

Testosterone and DHT signaling via androgen receptor in male development and physiology.

TestosteroneDHTDHEA+5

Cross-Referenced

3

— connected via related pathways

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Estrogen Signaling

Estrogen receptor-mediated regulation of reproduction, bone, and cardiovascular health.

17β-Estradiol (E2)Estrone (E1)Estriol (E3)+5