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Molecule

1 pathway

SERMs

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

17β-Estradiol (E2)×1 Estrone (E1)×1 Estriol (E3)×1 ERα×1 ERβ×1 GPER/GPR30×1 Coactivators (SRC-1/2/3)×1

Frequently Co-occurring Enzymes

Aromatase (CYP19A1)×1 17β-HSD×1 Sulfatase×1 SULT1E1 (sulfotransferase)×1

Cross-Referenced Pathways

1 direct · 3 cross-referenced · 4 shown

Direct Involvement

1

Estrogen Signaling

Estrogen receptor-mediated regulation of reproduction, bone, and cardiovascular health.

17β-Estradiol (E2)Estrone (E1)Estriol (E3)+5

Cross-Referenced

3

— connected via related pathways

Signal Transduction

MAPK/ERK Pathway

RAS–RAF–MEK–ERK cascade transducing growth factor signals to the nucleus.

Growth factors (EGF, PDGF)RAS-GTPRAF+3

Signal Transduction

PI3K/AKT/mTOR Pathway

Regulates cell survival, growth, and metabolism via phosphoinositide signaling.

PIP2PIP3AKT/PKB+6

Signal Transduction

G Protein-Coupled Receptor (GPCR) Signaling

Seven-transmembrane receptors activating heterotrimeric G proteins.

GPCRsGαs/Gαi/Gαq/Gα12Gβγ+6