Home/COX-1 (constitutive)

Enzyme

1 pathway

COX-1 (constitutive)

Found in 1 curated pathway across 1 category.

Interaction Network

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Active In Categories

Frequently Co-occurring Molecules

Arachidonic acid×1 PGH2×1 PGE2×1 PGI2 (prostacyclin)×1 TXA2 (thromboxane)×1 LTB4×1 LTC4/D4/E4 (cysteinyl leukotrienes)×1 Lipoxin A4×1

Frequently Co-occurring Enzymes

PLA2 (phospholipase A2)×1 COX-2 (inducible)×1 5-LOX×1 FLAP×1 Thromboxane synthase×1 Prostacyclin synthase×1

Cross-Referenced Pathways

1 direct · 2 cross-referenced · 3 shown

Direct Involvement

1

Lipid Metabolism

Eicosanoid Synthesis (Prostaglandins & Leukotrienes)

Arachidonic acid-derived lipid mediators regulating inflammation and vascular tone.

Arachidonic acidPGH2PGE2+5

Cross-Referenced

2

— connected via related pathways

Signal Transduction

NF-κB Pathway

Master regulator of inflammation, immunity, and cell survival.

NF-κB (p65/RelA, p50)IκBαIKKα/β/γ+4

Signal Transduction

Calcium Signaling

Ca²⁺ as a universal second messenger controlling diverse cellular processes.

Ca²⁺CalmodulinIP3+4